Sildenafil Citrate
Sildenafil Citrate is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). It works by relaxing smooth muscle and increasing blood flow to specific areas of the body, including the penis and pulmonary vasculature.
Dosage by Body Weight
For erectile dysfunction, the standard adult dose is 50 mg taken as needed, approximately 1 hour before sexual activity (range 25 mg to 100 mg, maximum once daily). For pulmonary arterial hypertension, standard dosing is 5 mg or 20 mg three times daily. Avoid concurrent use with nitrates or organic nitrites.
- Body Weight
- Below 5 kg
- Dose
- Not routine
- Frequency
- Use only if prescribed
- Tracking Notes
- Safety and efficacy not established in neonates; require specialist pediatric cardiologist supervision.
- Body Weight
- 5-7 kg
- Dose
- 0.5 mg to 1 mg per kg
- Frequency
- Three times daily
- Tracking Notes
- Indicated strictly for pediatric pulmonary arterial hypertension (PAH) under specialist direction.
- Body Weight
- 8-10 kg
- Dose
- 10 mg
- Frequency
- Three times daily
- Tracking Notes
- Oral suspension formulation is preferred for precise pediatric dosing.
- Body Weight
- 11-15 kg
- Dose
- 10 mg
- Frequency
- Three times daily
- Tracking Notes
- Adjust dosage carefully based on clinical response and tolerability.
- Body Weight
- 16-20 kg
- Dose
- 10 mg to 20 mg
- Frequency
- Three times daily
- Tracking Notes
- Monitor closely for adverse effects such as flushing, headache, or hypotension.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not routine | Use only if prescribed | Safety and efficacy not established in neonates; require specialist pediatric cardiologist supervision. |
| 5-7 kg | 0.5 mg to 1 mg per kg | Three times daily | Indicated strictly for pediatric pulmonary arterial hypertension (PAH) under specialist direction. |
| 8-10 kg | 10 mg | Three times daily | Oral suspension formulation is preferred for precise pediatric dosing. |
| 11-15 kg | 10 mg | Three times daily | Adjust dosage carefully based on clinical response and tolerability. |
| 16-20 kg | 10 mg to 20 mg | Three times daily | Monitor closely for adverse effects such as flushing, headache, or hypotension. |
Formulation
Purpose
Used for the treatment of erectile dysfunction (ED) and pulmonary arterial hypertension (PAH) to improve exercise capacity and delay clinical worsening.
Generic Name
Sildenafil CitrateBranded Drug Names
Sildenafil Citrate is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.